Prescription Vagifem (value) Drug Information

You should not use Vagifem if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, if you will have major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina. Do not use Vagifem if you are pregnant. Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away. Using Vagifem can increase your risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries. Vagifem should not be used to prevent heart disease, stroke, or dementia. You should not use Vagifem if you are allergic to estradiol, or if you have: unusual vaginal bleeding that has not been checked by a doctor; liver disease; a history of heart attack, stroke, or blood clot; an increased risk of having blood clots due to a heart problem or a hereditary blood disorder; or a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina. Do not use Vagifem if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Using Vagifem vaginal inserts can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke. Each Vagifem tablet is supplied in a single-use disposable applicator. Throw the tablet applicator away after one use. Instructions for use of the applicator: Tear off a single applicator. Separate the plastic wrap and remove the applicator from the plastic wrap. If after opening the package you see that the insert has come out of the applicator but has not fallen out of the package, carefully put it back into the applicator for insertion. Please keep your hands clean and dry while handling the insert. Hold the applicator so that the finger of one hand can press the applicator plunger. Next select the best position for vaginal insertion of Vagifem vaginal inserts that is most comfortable for you e.g. reclining or standing. Using the other hand, guide the applicator gently and comfortably through the vaginal opening. If prior to insertion the insert falls out of the applicator, throw the insert and applicator away and use a new insert-filled applicator. The applicator should be inserted (without forcing) as far as comfortably possible, or until half of the applicator is inside your vagina, whichever is less. Once the insert-filled applicator has been inserted, gently press the plunger until the plunger is fully depressed. This will eject the insert inside your vagina where it will dissolve slowly over several hours. After depressing the plunger, gently remove the applicator and dispose of it the same way you would a plastic tampon applicator. The applicator is of no further use and should be discarded properly. Insertion may be done at any time of the day. It is advisable to use the same time daily for all applications of Vagifem vaginal inserts. If you have any questions, please consult your healthcare provider or pharmacist.